Contain unmodified multilamellar liposomes similar to those used in most published depletion studies. Clodrosome-Clodronate Encapsulated Liposomes_ Package Insert Encapsula Nanosciences_2012 1. Standard macrophage depletion kit (Clodrosome, cat. . Alveolar macrophages (AMs) are pivotal for maintaining lung immune homeostasis. Macrophage depletion. In order to deplete LN-resident macrophages, 0.25 mg (50 μl) of Clodrosome (CLL) and Encapsome (control liposome) were subcutaneously injected 5 days prior to each vaccination. Intraperitoneal administration of 200 μl of Encapsome or clodronate liposomes (5 mg/ml) was performed three times at 7 days apart . 24,25 Clodrosome was suspended in phosphate-buffered saline (PBS), 1 mL of suspension contained 5 mg clodronate, 18.8 mg phosphatidylcholine, and 4.2 mg cholesterol. Clodronate liposomes or empty liposomes were injected into mice 36 h before tMCAO (i.p., 75 mg/kg). administered one day before the third and fourth dose of +--++--+. Home; About the conference. A Clodrosome Macrophage Depletion Kit, containing control liposomes (Encapsome) and clodronate liposomes (Clodrosome) (Encapsula NanoSciences, Brentwood, TN), was used to deplete endogenous monocytes/macrophages. For macrophage depletion, OS17 solid tumor-bearing nude mice were injected with liposomal clodronate (Clodrosome; Encapsula NanoSciences LLC, Brentwood, TN, USA) intraperitoneally 6 days prior to MSC injection and then every 3 days to maintain depletion. Encapsome® is formulated and prepared identically to Clodrosome® except that clodronate is not added to the liposomes. Depletion of alveolar macrophages reduces mouse cytomegalovirus (MCMV)-3DR infection in the neonatal lung. Control rats were injected with the same amount of encapsome (control liposomes). A Clodrosome Macrophage Depletion Kit, containing control liposomes (Encapsome) and clodronate liposomes (Clodrosome) (Encapsula NanoSciences, Brentwoood, TN), was used to deplete endogenous monocytes/macrophages. Intraperitoneal administration of 200 µl of placebo or clodronate liposomes (5 mg/ml) was performed once daily for three consecutive days. ENCAPSULA NANAOSCIENCE LLC MACROPHAGE DEPLETION KIT 2ML . the Clodrosome® standard macrophage depletion kit (containing Clodronate liposome and control liposomes), and know how . ( a - j ) Phosphate-buffered saline (PBS), encapsome, or clodrosome was . 200 µL of either Clodrosome (liposome encapsulated clodronate) or Encapsome (empty liposomes as vehicle control) was intravenously (i.v.) For macrophage depletion, Clodrosome or Encapsome was used from the standard macrophage depletion kit (Encapsula NanoSciences, Brentwood, TN) as suggested. Apr 23rd. Five animals received clodronate liposomes and five animals received control liposomes. Clodrosome Macrophage Depletion Kits and Reagents. Locally delivered liposomal clodronate in matrigel effectively inhibited the activation of macrophages, immune cell migration and activation, and pro-inflammatory cytokine secretion from macrophages. Mice were maintained under specific-pathogen-free conditions in the vivarium of Emory Vaccine Center. Macrophage depletion kit is composed of one vial of Clodrosome® and one vial of Encapsome®. Standard Macrophage Depletion Kit (Clodrosome® + Encapsome®) DESCRIPTION Clodrosome® is a multilamellar liposome suspension in which clodronate is encapsulated in the aqueous compartments of the liposomes. A clodronate macrophage depletion kit, containing control liposomes (encapsome) and clodronate liposomes (clodrosome) (Encapsala NanoSciences, Brentwoood, TN), was utilized to deplete endogenous myeloid cells. Standard macrophage depletion kit . When tumors became palpable, subcutaneous injection of 200 µL (5 mg/mL) of Clodrosome (clodronate-encapsulated liposomes), or vehicle Encapsome (PBS liposomes), was administered twice per . To order using a credit card, select a volume of the desired product and click "add to cart". macrophages in vivo. As an example, a 5-ml kit is composed of 5 ml m-Clodrosome® and 5 ml m-Encapsome®. NC1643785. Encapsula has no control over the Caspio Server Status, however if you experience excessive access issues, please email us at info@encapsula.com with the details. ; 200 μl; 5 mg/ml) three times at seven days apart during the RS paradigm . These kits are also available with various fluorescent control reagents such as DiI (ex/em: 549/565 nm), DiO (ex/em:484/501 nm), DiD (ex/em: 644/665 nm), DiA (ex/em: 456/590 . on days −2, −1, and 0 followed by weekly i.p. Micron sized liposomes engineered specifically to target macrophages in different tissues and organs. Contact Encapsula NanoSciences LLC 5409 Maryland Way Suite 360 Brentwood, TN 37027 Phone: 615-884-4442 Fax: 615-250-8747 URL: www.encapsula.com Clodronate has previously been used to deplete the number of macrophages in the lungs. BASIQ 2021. 10010049) no. Liposome size range (0.3-3 µm) is optimal for immediate phagocyte recognition and uptake. Standard macrophage depletion kit- The kit is composed of one 2 ml vial of Clodrosome (Clodronate liposomes) and one 2 ml vial of Encapsome (plain liposomes for control). Conference Chairs Select quantity or request quotation for larger quantities. Tuber analysis was used to further determine angiogenetic effect . PD-L1 expression was observed in human OS cells and OS patient lung metastases. Encapsome® is formulated and prepared identically to Clodrosome® except that clodronate is not added to the liposomes. The clodronate-containing liposomes will be recognized as foreign particles and get . A clodronate macrophage depletion kit, containing control liposomes (Encapsome) and clodronate liposomes (Clodrosome; Encapsala NanoSciences), was used to deplete endogenous myeloid cells. How does Clodrosome® (Clodronate encapsulated liposome) kill macrophages? For macrophage depletion, mice were intrathecally injected on day 4 after the first dose of cisplatin under isoflurane anesthesia with 10 μL of either empty liposomes or clodronate-containing liposomes from the mannosylated macrophage depletion kit (catalog CLD-8914, Encapsula Nano Sciences) . no. Click on "More Info" for product details, or if you. Clodrosome is a Liposomal Clodronate, and Encapsome is the Control Liposomes. on day −3 and intraperitoneally (i.p.) Hematogenous macrophages were depleted with clodronate liposomes. Hi, did anyone use the Clodrosome® standard macrophage depletion kit (containing Clodronate liposome and control liposomes), and know how to prepare it before injection? CD1 wild-type and TCF/Lef:H2B-GFP reporter mice mice were injected with a macrophage depletion kit Clodrosome and Encapsome (Encapsula NanoSciences). When tumors became palpable, subcutaneous injection of 200 µL (5 mg/mL) of Clodrosome (clodronate-encapsulated liposomes), or vehicle Encapsome (PBS liposomes), was administered twice per . Depletion of tumor-associated macrophages decreases the growth of tumors in the transplantable tumor model. Macrophage Depletion. Cell depletion confirmed by flow cytometric analysis of splenocytes for NK (CD49d+) or . Cytotoxicity of Bisphosphonates such as Clodronate, Pamidronate and Zelodronate. Hi, did anyone use the Clodrosome® standard macrophage depletion kit (containing Clodronate liposome and control liposomes), and know how to prepare it before injection? To deplete macrophages, 2.5ml clodrosome (Liposomal Clodronate, 5 mg/ml, Clodrosome Macrophage Depletion kit, Encapsula Nano Science) were injected into a rat through the Apr 23rd. Empty liposomes were injected as the control (Clodrosome Macrophage Depletion Kits, Clodrosome). Could you kindly provide . At 24 h after clodrosome treatment, AMin BALF signifi-cantly decreased from ∼30 to ∼2% (Fig. Encapsula Nanosciences. 4-Aminophenyl-alpha-D- Mannopyranoside incorporated into the liposomes. Clodrosome巨噬细胞消耗试剂盒包含与大多数已发表的枯竭研究中使用的类似的未修饰的多层脂质体脂质体大小范围（0.3-3 m）对于立即吞噬细胞的识别和摄取是zui佳的试剂盒包含相同体积的 . Macrophage depletion has been used extensively to study autoimmune disease and more recently in tumor models. Large selection of macrophage/monocyte depletion kits and reagents. Large selection of macrophage/monocyte depletion kits and reagents. Dec 16th. The effect of tumor macrophages on oncolytic virus therapy, however, is variable among solid tumors and is unknown in Ewing sarcoma. Clodronate-liposome treatment is widely used for macrophage depletion, . Lipid Nanoparticles. on day −3 and intraperitoneally (i.p.) Anti-PD1 antibody led to a significant decrease in the number of OS lung metastases, enhanced tumor apoptosis, decreased tumor cell proliferation, and p-STAT-3/p-Erk1 . Especially, the inhibition of macrophage attack in the early stage after local delivery of islets was very important for the successful long-term survival of delivered islets. 1A). Catalog No. Encapsula NanoSciences is a specialty company focused on providing liposome research, development and manufacturing expertise in the production of lipid-based nanoparticles, also known as liposomes, to clients and partners in both the academic and industrial sectors. To further confirm this finding, we performed a macrophage-depletion treatment experiment using the agent Clodrosome (liposomal clodronate; Encapsula NanoSciences LLC), a liposome suspension encapsulated with clodronate, which selectively leads to macrophage apoptosis . For macrophage depletion, mice were given a two-dose vaccination of parental BCG, rBCG1, or rBCG2 (5 × 10 5 CFU per mouse) subcutaneously at weeks 0 and 2, and they received one drop of encapsome® (control) or clodrosome® (Encapsula Nano Sciences, TN, USA) intratracheally weekly for 8 weeks. Large selection of macrophage/monocyte depletion kits and reagents. Naïve tumors showed significantly more positive area of F4/80 using IHC . Macrophages are present in nearly every tissue of the body and are important for maintaining homeostasis, but their dysfunction can also lead to diseases, such as inflammatory bowel disease. For the CD1 wild-type, the animals were injected 200 μl of either solution intraperitoneally. 7 A). need details on ordering and payment, see the Ordering Info page. Macrophage depletion in mice Macrophage depletion in vivo used Clodrosome, WT-RDNV/CLD, KO-RDNV/CLD, and the PBS control with equal amounts of clodronate. Macrophages infiltrating the colon cancers in this model secrete the inflammatory mediators CCL2, IL-1a, IL-6 and TNFa. Catalog No. Mice, with or without AMdepletion, were subjected to HS and resuscitation, and at 8 h afterresuscitation,alveolarPMNsweredefinedasLy6G-positivecells by flow cytometry, and cell death was assessed by double-positive for tissues (PD-L1, caspase-3, Ki-67, NK cells, macrophages), and Western blot-ting for OS lung tumors (p-Stat3, p-Erk1/2) was performed. 8901) Trypsin/EDTA solution (Life Technologies, cat. m-Clodrosome® and m-Encapsome® are mannosylated reagents that are specifically formulated to efficiently target the macrophages in central nervous systems and . For in vivo macrophage depletion, 6- to 8-week-old female C57BL/6 mice received one or three intravenous injections (on days −3, 0, and 3 with respect to DNA vaccination) of 750 μg clodronate disodium formulated in clodrosome (150 μL injection, Encapsula Nanoscience) via retro-orbital injections and control mice each received 150 μL of . CD1 wild-type and TCF/Lef:H2B-GFP reporter mice mice were injected with a macrophage depletion kit Clodrosome and Encapsome (Encapsula NanoSciences). Several strategies were taken to verify the contribution of M2 macrophage and CHI3L1: macrophage depletion by clodrosome, local CHI3L1 inhibition using intravitreally injection neutralize antibody (mAY), and depletion of CHI3L1 receptor (IL13-Ra2) by small-interfering RNA (siRNA). Menu. The subcellular fractionation study indicates that mannose labeled liposomes are incorporated into lysosomes rich fraction both in liver and brain. NK cell and macrophage depletion were conducted using anti-asialo GM1 and clodrosome, respectively. Clodrosome is a Liposomal Clodronate, and . . Dec 16th. To study the role macrophages play in a complex in vivo environment, depletion and reconstitution experiments can be utilized. Ccl2, Il1a and Il6 are consequently downregulated in tumors from CCR6-deficient mice. treatments. Clodrosome Depletion of Macrophages Enhances OV Efficacy (A) Treatment regimen of A673 tumor xenograft-bearing mice given 400 μg of liposome or Clodrosome intravenously (i.v.) R001100) PBS (Life Technologies, cat. Adoptive transfer. Could you kindly provide . Standard Macrophage Depletion Kit (Clodrosome + Encapsome) was purchased from Encapsula Nanosciences (CLD-8901). The kits come in 2 different varieties: standard kits and mannosylated kits (mainly to target central nervous system). As an example, a 5-ml kit is composed of 5 ml Clodrosome® and 5 ml Encapsome®. Treatment with m-Clodrosome, but not the control liposome (Encapsome), prevented the MCP-1/sSiglec-9-mediated conversion of the FNI-induced pro-inflammatory environment to an anti-inflammatory one (Fig. PD-L1 expres- The depletion of T cells and macrophages were conducted as previously described.30 Mice-bearing 4T1 tumor were intraperitoneally injected twice before the initial treatment at a 72 hours interval with anti-CD8 antibodies (400 µg, BioXCell, West Lebanon, USA, clone 2.43), anti-CD4 antibodies (400 µg, BioXCell, clone GK1.5), or clodrosome (50 . Michael D. L. Johnson, a. Thomas E. Kehl-Fie, Manufacturer: ENCAPSULA NANAOSCIENCE LLC CLD89142ML Mannosylated Macrophage Depletion Kit (m-Clodrosome® + m-Encapsome®) 2ml. The median survival time of transplanted islets (Islet-Matrigel-Clodrosome group) was significantly increased (>60 days), compared to other groups. Ewing sarcoma is a highly aggressive cancer that promotes the infiltration and activation of pro-tumor M2-like macrophages. no. The liposomes are filtered through 2 μm polycarbonate membranes to ensure that the larger particles, which may be toxic to animals, are . Oncolytic virotherapy that selectively infects and destroys cancer cells is a promising option for treating Ewing sarcoma. Forty hours after clodrosome or encapsome injection, the rats were injected ip . Clodronate-liposome treatment is widely used for macrophage depletion, . used a clodrosome macrophage depletion kit (Encapsula Nano Sciences, Nashville, TN). Mannosylated macrophage depletion kit is composed of one vial of m-Clodrosome® and one vial of m-Encapsome®. Encapsula Nano S ciences Product Information Version: 02/15/12 Clodrosome® Macrophage Depletion Kit Refrigerate at 4°C - DO NOT FREEZE Kit Contents: 1. Keynote-Speakers; Board. We next examined how M2 macrophage depletion by m-Clodrosome affects the MCP-1/sSiglec-9-mediated FN regeneration. For macrophage depletion, Clodrosome or Encapsome was used from the standard macrophage depletion kit (Encapsula NanoSciences, Brentwood, TN) as suggested. The mice were anesthetized by inhalation of 4% isoflurane (Piramal), then each mouse in the . Control mice were given the same amount of control liposome suspension. Control rats were injected with the same amount of encapsome (control liposomes). Clodrosome Depletion of Macrophages Enhances OV Efficacy (A) Treatment regimen of A673 tumor xenograft-bearing mice given 400 μg of liposome or Clodrosome intravenously (i.v.) The information in the Announcement section below the server status section may give you an idea about when to expect the issues to be resolved. 8901) every 3 days from 6 to 12 days P.I. Mannosylated Clodrosome Macrophage Depletion Kits. Below is a complete list of our Clodrosome Macrophage Depletion Products. Macrophage depletion. Standard macrophage depletion kit (composed of one vial of Clodrosome® and one vial of Encapsome®) NC0302518 $272.80 / Each We used the Clodrosome® Fluorescent-DiI Macrophage Depletion Kit (Encapsula Nano Sciences, Brentwood, TN), which includes a suspension of 1.5-2 μm liposomes consisting of non-toxic L-alpha-phosphatidylcholine and cholesterol, labeled with 1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindocarbocyanine (DiI) and containing either disodium . treatments. Large selection of macrophage/monocyte depletion kits and reagents. NK cell and macrophage depletion were conducted using anti-asialo GM1 and clodrosome, respectively. Standard macrophage depletion kit (composed of one vial of Clodrosome® and one vial of Encapsome®) Clodrosome® is a multilamellar liposome suspension in which clodronate is encapsulated in the aqueous compartments of the liposomes. To deplete macrophages, 2.5 ml clodrosome (Liposomal Clodronate, 5 mg/ml, Clodrosome Macrophage Depletion kit, Encapsula Nano Science) were injected into a rat through the tail vein. To deplete macrophages, 2.5 ml clodrosome (Liposomal Clodronate, 5 mg/ml, Clodrosome Macrophage Depletion kit, Encapsula Nano Science) were injected into a rat through the tail vein. mice i.t. Locally co-delivered pancreatic islets and liposomal clodronate using injectable hydrogel effectively cured type 1 diabetes. How does Clodrosome® (Clodronate encapsulated liposome) kill macrophages? the Clodrosome® standard macrophage depletion kit (containing Clodronate liposome and control liposomes), and know how . NK and macrophages were assessed using flow cytometry. Mice were injected IP with 80µl containing 0.4mg clodronate or control liposomes (Clodrosome macrophage depletion kit, Encapsula Nano Sciences; Brentwood, TN; No. $396.80 / Each; Qty Add to cart . Macrophage depletion also remarkedly diminished large platelet aggregate formation in the splenic marginal zone but had less effect on those in red pulp. on days −2, −1, and 0 followed by weekly i.p. The mannosylated-Clodrosome Macrophage Depletion Kit (m-Clodrosome: 5 mg/ml Clodronate Disodium Salt, 18.8 mg/ml L-α-Phosphatidylcholine, 4.2 mg/ml Cholesterol, and 1 mg/ml 4-Aminophenyl-alpha-D-Mannopyranoside; Encapsula NanoSciences, Brentwood, TN, United States) was used to deplete M2 macrophages from the PSL mice. Article Snippet: Phagocyte depletion using clodronate liposomes Naïve female mosquitoes (4- to 6-day old) were injected intra-thoracically with either 69 nl of control liposomes (LP) or clodronate liposomes (CLD) (Standard macrophage depletion kit, Encapsula NanoSciences LLC) using a Nanoject II injector (Drummond Scientific). We demonstrated that deletion of liver kinase b1 (Lkb1) in CD11c+ cells led to greatly reduced AM abundance in the lung due to the impaired self-renewal of AMs but not the impeded pre-AM differentiation. Liposomal clodronate suspension (500 mg/mouse) was administered intratracheally in a volume of 100 ml 3 h after the coad-ministration of IL-33 and IL-17A. Mice with Lkb1-deficient AMs exhibited deteriorated diseases during airway Staphylococcus aureus (S. aureus . and sacrificed at 14 days P.I. Cytotoxicity of Bisphosphonates such as Clodronate, Pamidronate and Zelodronate. The depletion of T cells and macrophages were conducted as previously described.30 Mice-bearing 4T1 tumor were intraperitoneally injected twice before the initial treatment at a 72 hours interval with anti-CD8 antibodies (400 µg, BioXCell, West Lebanon, USA, clone 2.43), anti-CD4 antibodies (400 µg, BioXCell, clone GK1.5), or clodrosome (50 . Encapsome or clodronate liposomes were administered (i.p. Macrophage Depletion Kit (Standard) Each standard macrophage depletion kit contains one vial of Clodronate encapsulated liposomes (Clodrosome) and one vial of plain liposome for control (Encapsome) with the same lipid composition as Clodrosome. Read More. Depletion of macrophages by clodrosome resulted in reduction of LPS-induced cytokine generation and alleviated LPS-induced thrombocytopenia. The doses of injected clodronate were 25 and 12.5 μg per g body weight per day for day 0 and day 1, respectively. 3 - 5 June 2021, The University of Foggia, Italy. a Representative images of tissue sections immunostained for macrophages (F4/80), B cells (B220) or T cells (CD3, CD8, Foxp3) in gastric tumor sections of gp130 FF; c-Kit +/+ and mast cell . Role of Copper Efflux in Pneumococcal Pathogenesis and Resistance to Macrophage-Mediated Immune Clearance. The inflammatory mediators CCL2, Il1a and Il6 are consequently downregulated in tumors from CCR6-deficient mice PBS... 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