Enrollment: 2010-12-01 - 2015-04-30. PI: Prof Hasse Karlsson; co-PI: Adj. Braun JM, Daniels JL, Poole C, et al. The team of researchers assessed DNA . | Find, read and cite all the research you . Sahra Gibbon is an Associate Professor in Medical Anthropology at UCL where she convenes the MSc in Biosocial Medical Anthropology. ECHO, or the E nvironmental Influences on C hild H ealth O utcomes Program, is a seven-year initiative started by the National Institutes of Health aimed at understanding the effects of environmental exposures on child health and development. Chan School of Public Health, and Honorary . Response: In this study, we examined whether father's weight status (body mass index) at the time of conception was associated with epigenetic marks and weight status in the offspring. We analyzed associations between first-trimester urine concentrations of 8 phenols and 11 phthalate metabolites and expression of 29 candidate miRNAs in placenta by qRT-PCR. We investigated the association of SES with AA in more than 5,000 individuals . 2020 01 31. Expected number of children in cohort: 4040. The aim of this study is to investigate the association between maternal pre-pregnancy body mass index (BMI) and miRNA . The discrepancy between gestational age predicted from DNA methylation and determined by ultrasound or last menstrual period is known as gestational age acceleration. Braun J, Daniels J, Poole C, et al. She is a member of the international Biosocial Birth Cohort Research (BCCR) network and the Principal Investigator of the NHGRI-funded K99/R00 study "Behavioral Epigenetics in Children: Exploring the Social and Ethical Implications of Translation" (R00HG009154). Her research focuses on lived experiences of health, science, and medicine. in the identification of the key epigenetic toxicants complex exposures, as well asanysex-specific DNA methylation changes associated with the same exposure setting. In this context, maternal pre-pregnancy weight might modify fetal metabolism and the child's predisposition to develop disease later in life. Epigenetics refers to mitotically heritable changes to the DNA, which do not affect the DNA sequence, but can. Wang and her team have established three large study cohorts (Boston Birth Cohort, Chicago Family-based Cohort, and Chinese Twin Cohort). Data and biospecimens used in this study were from 147 participants of the Epigenetic Birth Cohort comprising 1941 mother-child dyads recruited between June 2007 and June 2009 at the Department of Obstetrics, Gynecology and Reproductive Biology at Brigham and Women's Hospital (BWH) in Boston, MA, USA. Dr. Hivert is an Associate Professor in the Department of Population Medicine at Harvard Medical School. Number of Epigenetic Publications since 1990 Burris & Baccarelli, J Applied Toxicol 2013 142 348 567 1567 5117 13771 12 21 110 247 0 2000 4000 6000 8000 10000 12000 14000 1990 1993 1996 1999 2002 2005 2008 2011 Epigenetics Environmental Epigenetics Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936 Authors: Robert F. Hillary 1 , Daniel L. McCartney 1 , Sarah E. Harris 2,3 , Anna J. Stevenson 1 , Anne Beginning with the Early Teen visit, we allowed participants to provide consent specifically for epigenetic analysis of their biosamples—whether obtained in the past, The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond. Provided blood or nasal swab samples at one or more in-person visits b. Child pregnancy and birth outcomes. Director, Harvard Education and Research Center for Occupational Safety and Health Physician, Pulmonary and Critical Care Division, Department of Medicine, Massachusetts General Hospital. The Dutch Famine cohort is one of the most well-known cohorts that have been used to investigate the effects of prenatal undernutrition in humans. Child obesity and cardio-metabolic outcomes. Mode of delivery and cord blood cytokines: a birth cohort study. Assisted Reproductive Technologies (ART) have resulted in more than 7 million births since 1978 1.Today, ART procedures are diverse, spanning the relatively less invasive intervention of gamete . Whether environmental risk factors affect preterm birth through epigenetic phenomena is largely unstudied. a Fogarty Global Health Fellow at the Harvard T.H. Addressing Mental Health in the Second Decade of Life through Translational Lifecourse Research. To determine if maternal metabolite levels impact infant DNA methylation globally and at growth and development genes, we followed a clinical birth cohort of 40 mother-infant dyads. Preterm birth can lead to increased mortality risk and poor life-long health and neurodevelopmental outcomes. "Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIRONAGE birth cohort study." Duration and Life-Stage of Antibiotic Use and Risks of All-Cause and Cause-Specific Mortality: Prospective Cohort Study. 2010. We examined associations of maternal and umbilical cord blood long interspersed Project Viva is a longitudinal pre-birth cohort study. Case-cohort sample of the Danish National Birth Cohort, which is a population-based birth cohort Denmark 1996-2002 91 387 (DNBC) 3908 (GOYA) European 49 1000 children equally sampled from extreme obese GOYA mothers (cases) and GOYA control mothers Healthy Start 27133623, 26872289, 26663829, 26055075, 25646327, 25628236, 25574704 Environmental Health. Prospective cohort study of intervention on CKDnt; Register study of precarious employment in Sweden Risk management in communities and for hospitals, pharmacoepidemiology, and energy conservation. That's why it's crucial to provide supportive and nurturing experiences for young children in the earliest years. 2006 Sep 26; 4:13. We initially reported elevated exposures to methylmer- The study, conducted by scientists at the University of Southampton, uncovered a connection between season of birth and epigenetic marks, specifically DNA methylation. EDC (phenols and phthalates) biomarker concentrations were measured in maternal spot urine samples during the first trimester and telomere length in maternal and cord blood . The out-of-sample prediction cohort: Lothian Birth Cohort 1936. My major research interests are occupational, environmental and molecular epidemiology. Data and biospeci-mens for the HEBC were collected from June 2007 through June 2009; the cohort includes 1,941 mother-child dyads (Michels et al. Jie Hu, MD, PhD Sex differences in the intergenerational link between maternal and neonatal whole blood DNA methylation: An analysis in the Boston Birth Cohort . Given pre- The establishment of a longitudinal birth cohort of twins vious heritability estimates, we are particularly interested with sufficient depth of data and biospecimen collection in exploring the relationship between epigenetic and phe- to show broad utility in epigenetic epidemiology is a TWIN RESEARCH AND HUMAN GENETICS OCTOBER 2012 5 . Tag: Epigenetics. We compare our method to a distributed lag model approach that models DNA methylation in a probe-by-probe manner, both in simulation and by application to motivating data from the Project Viva birth cohort. Consented to use of their biospecimen samples for epigenetic analysis. Epigenetics and genetics. This epigenetic revelation could even be the missing piece to the mechanism underlying many other seasonally influenced diseases and traits. rapidly, cause epigenetic adaptations that influence whether, when, and how genes release their instructions for building future capacity for health, skills, and resilience. Provided blood or nasal swab samples at one or more in-person visits b. A . Recently, cord blood DNA methylation data has been used to predict gestational age. PDF | Why was the Consortium set up? Participants were recruited from electoral rolls, advertisements, and community announcements with oversampling of Italian and Greek migrants (30% of . Epigenetic reprogramming facilitates fetal adaptation to these in utero cues. Along with extensive epidemiological and clinical data as well as related biorepositories, these cohorts are well-designed for studying a broad range of health and disease outcomes and early life precursors . We examined the association between maternal gestational concentrations of biomarkers of EDC exposure and telomere length at birth in the Harvard Epigenetic Birth Cohort. First trimester urine concentrations of 8 phenols and 11 phthalate metabolites were measured and used to characterize EDC exposure profiles. Clin Mol Allergy. 7 , 28-28 (2007). BMC Geriatr. This presentation demonstrates the new capabilities of PowerPoint and it is best viewed in Slide Show. The Melbourne Collaborative Cohort Study is an ongoing cohort study of 24,479 women and 17,049 men aged 27-75 years (99.3% aged 40-69) who resided in Melbourne Australia between 1990 and 1994. DNA methylation and the epigenetic clock in relation to physical frailty in older people: the Lothian Birth Cohort 1936 Catharine R. Gale1,2,3*†, Riccardo E. Marioni2,4†, Sarah E. Harris2,4, John M. Starr2,5 and Ian J. Deary2,3 Abstract Background: The biological mechanisms underlying frailty in older people are poorly understood. This study investigated associations of sex, socioeconomic status . Here, DNAm was assessed in blood samples from wave 1 of the study between 2004 and 2007. Research. Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIRONAGE birth cohort study Bram G Janssen1, Hyang-Min Byun2, Wilfried Gyselaers3,4, Wouter Lefebvre5, Andrea A Baccarelli2, and Tim S Nawrot1,6,* 1Centre for Environmental Sciences; Hasselt University; Diepenbeek, Belgium; 2Laboratory of Environmental Epigenetics; Exposure . • Four cohorts (approximately 6000 subjects) - Framingham - Lothian Birth Cohort 1921 - Lothian Birth Cohort 1936 - Normative Aging Study DNA methyltransferase 3 alpha (DNMT3A), which is involved in de novo DNA methylation (DNAm), is a prime candidate gene as a mediator between prenatal exposures and birth outcomes.We evaluated the relationships between in utero arsenic (As) exposure, birth outcomes, and DNMT3A DNAm. With the guidance of my mentoring team, during this 5 year K23 career development award, the Candidate will leverage data from two prospective longitudinal cohorts of mothers and children (Project Viva, n=2,128 and the New Hampshire Birth Cohort Study (NHBCS), n=1,500) to extend this prior work through three inter-related projects. 1989). The Socio-Environmental Research Group (SERG) is pleased to announce an in-person conference titled "Social and environmental exposures and the developmental origins of health disparities" that will take place in Portland, OR on April 21st and 22nd, 2022. RESULTS: To assess the mechanistic aspects of fetal programming, we measured genome-wide methylation (Infinium HumanMethylation450 BeadChips) and expression (Affymetrix transcriptome microarrays) in placental tissue of 41 GDM cases and 41 matched pregnancies without maternal complications from the Harvard Epigenetic Birth Cohort. Genome-wide profiling identifies epigenetic alterations at birth preceding diagnosis of childhood leukaemia. Alexandre Trapp, BS Profiling epigenetic age in single cells. that metastatic ability can be the consequence of a single genetic or epigenetic change, such as genetic inactivation of SMAD4, high expression levels of RUNX3, or epigenetic reprogram-ming [4, 6-8, 25]. … Obstetric risk factors for early-onset schizophrenia in a Finnish birth cohort. FinnBrain Birth Cohort Study. To address these challenging questions, we took advantage of a birth cohort in the Faroe Islands born in 1986-1987 [16,17]. ECHO will provide funding to many existing, longitudinal studies, like Project Viva, with the goal of . cohort who: a. We sought … with body‐mass index in the discovery cohort In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). Therefore, the timing of exposure during pregnancy is an important factor that may influence the outcome of exposure. Directs and integrtes the work of experts in environmental health, biostatistics, epidemiology, toxicology, and engineering University of Turku, Institute of Clinical Medicine, Turku Brain and Mind Center, Lemminkäisenkatu 3a, Building:Teutori, 200, Finland (Suomi) More details. In two epigenetic regions selected based on prior studies of air pollution effects on epigenome-wide methylation, we identify windows of . Therefore, we conduct genome- and epigenome-wide association studies on the levels of 92 neurological proteins to identify genetic and epigenetic loci associated with their plasma concentrations (n = 750 . Targeted metabolomics and quantitative DNA methylation were analyzed in 1st . For example, a birth cohort study of 1390 women found that arsenic concentrations in the third trimester, but not in the first and second trimesters, were negatively associated with birth weight and birth length . Methods: Our study was restricted to a total of 179 women co-enrolled in the Harvard Epigenetic Birth Cohort and the Predictors of Preeclampsia Study. Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Results: To assess the mechanistic aspects of fetal programming, we measured genome-wide methylation (Infinium HumanMethylation450 BeadChips) and expression (Affymetrix transcriptome microarrays) in placental tissue of 41 GDM cases and 41 matched pregnancies without maternal complications from the Harvard Epigenetic Birth Cohort. Laboratory of Environmental Epigenetics . Birth cohort studies have become the gold-standard method for tracing the intergenerational transmission of stress primarily due to the major focus on the developmental origins of health and disease framework in public health (Barker et al. This interdisciplinary event will showcase cutting-edge research focused on the joint contribution of . PMID: 31842690. Chan School of Public Health. Child asthma and allergies. Beginning with the Early Teen visit, we allowed participants to provide consent specifically for epigenetic analysis of their biosamples—whether obtained in the past, The genetic and epigenetic profile of serum S100β in the Lothian Birth Cohort 1936 and its relationship to Alzheimer's disease. Maternal diet and metabolism impact fetal development. Article Google Scholar 2015. Heianza Y, Ma W, Li X, Cao Y, Chan AT, Rimm EB, Hu FB, Rexrode KM, Manson JE, Qi L. Circ Res. Epigenetics & Environmental Epidemiology. Techniques from cancer epidemiology and time series analysis were used to explore the hypothesis that cosmic radiation can induce germ cell changes leading to increases in future breast cancer mortality. Since 1990, Dr. Hu has led multi-institutional and international teams of scientists, students and fellows devoted to investigating the environmental, nutritional, social, psychosocial, genetic and epigenetic determinants of chronic disease and impaired child development in birth cohort and aging cohort studies around the world. Our study was restricted to a total of 196 women co-enrolled in the Predictors of Preeclampsia Study and the Harvard Epigenetic Birth Cohort. cohort who: a. Chan School of Public Health . Addis Ababa Birth Cohort (ABC) Neonatal infections cause approximately 557,000 neonatal deaths worldwide every year and account for the greatest proportion of neonatal deaths in Ethiopia, yet there are limited studies investigating the modes of acquiring neonatal infection and identifying risk factors (maternal, neonatal, biological) in order . Type-0 cells divide and die at specified rates per time unit and may give rise to type-1 cells with a mutation rate u per cell division . Although plasma proteins may serve as markers of neurological disease risk, the molecular mechanisms responsible for inter-individual variation in plasma protein levels are poorly understood. Gestational age at delivery is associated with health and social outcomes. Danni A Gadd, Robert I Mcgeachan, Robert F Hillary, Daniel L Mccartney, Sarah E Harris, Roy A Sherwood, N Joan Abbott, Simon R Cox, Riccardo E Marioni. 1999. Powerful ideas for a healthier world Step by Step Tutorial. LBC1936 [33, 34] was used for external DNAm predictions. 2016 Cohort. To assess the mechanistic aspects of fetal programming, we measured genome-wide methylation (Infinium HumanMethylation450 Beadchips) and expression (Affymetrix Transcriptome Microarrays) in placental tissue of 41 GDM cases and 41 matched pregnancies without maternal complications from the Harvard Epigenetic Birth Cohort. Citation Janssen, Bram G, Hyang-Min Byun, Wilfried Gyselaers, Wouter Lefebvre, Andrea A Baccarelli, and Tim S Nawrot. Since 1999, Project Viva has collected high quality data in the following focus areas. Background: Fetal epigenetic programming plays a critical role in development. Photo by Kent Andersen. Consented to use of their biospecimen samples for epigenetic analysis. LBC1936 is a cohort comprising individuals born in 1936, who were aged approximately 70 years at recruitment. Methods: Our study was restricted to a total of 179 women co-enrolled in the Harvard Epigenetic Birth Cohort and the Predictors of Preeclampsia Study. A prospective cohort study of biomarkers of prenatal tobacco smoke exposure: The correlation between serum and meconium and their association with infant birth weight. Dutch Famine Birth Cohort Insights in the importance of nutritional supply during a critical period on long-term disease outcome were gained from the Dutch Famine cohort. Laboratory of Environmental Epigenetics Harvard School of Public Health PG16: Epigenetics of Lung Disease Designing Studies of DNA . A birth cohort is a group of individuals born during a given calendar time period within a specified geographical region. She is a clinical investigator with primary focus on the etiology and primordial prevention of obesity and related co-morbidities, particularly type 2 diabetes and gestational diabetes. 2011). In this initiative, sponsored by the Harvard Catalyst Child Health Committee, the community was invited to submit applications for pilot grants to foster and enable collaborative research on mental health and the developing brain in the second decade of life across the T1-T4 translational spectrum. Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936.pdf Available via license: CC BY 4.0 Content may be subject to copyright. This means the old idea that genes are "set in stone" has been disproven. This score utilises previously derived weights calculated in an independent sample and has been previously shown to robustly reflect smoking status 20 . Maternal pregnancy and post-partum health outcomes. We analyzed associations between first-trimester urine concentrations of 8 phenols and 11 phthalate metabolites and expression of 29 candidate miRNAs in placenta by qRT-PCR. Marie-France Hivert. in two large birth cohorts, the Harvard Epigenetic Birth Cohort (HEBC) and the Predictors of Preeclampsia Study (POPS) at the Brigham and Women's Hospital in Boston, Massachusetts. A birth cohort time series for female breast cancer mortality was obtained using a model-independent, age-period-cohort analysis on age-specific mortality data for 1940-1990. There is increasing evidence that the predisposition for development of chronic diseases arises at the earliest times of life. Child development. Chan School of Public . For example, the U.S. 1950 annual birth cohort refers to the group of people born in the United States during the . Preterm birth affects over 12% of all infants born in the US yet the biology of early delivery remains unclear, including whether epigenetic mechanisms are involved. Schizophrenia Research. • If epigenetic age is different from chronological (real) age, do individuals with epigenetic age higher than chronological age have shorter life expectancy? A new study conducted by scientists in the Epigenomics and Mechanisms Branch at the International Agency for Research on Cancer (IARC), in collaboration with a large international network of collaborators, provides new evidence that molecular (epigenetic) alterations associated with . at birth In-utero exposures Epigenome in childhood Early life exposures Preconceptional exposures Epigenome . Prenatal Tobacco Smoke Exposure and Early Childhood BMI. She is the founder and convenor of the international cross-disciplinary Biosocial Birth Cohort Research (BBCR) network and PI of a Wellcome Trust Investigator Award 'The Biosocial Lives of Birth Cohorts'. "Epigenetics" is an emerging area of scientific research that shows how environmental influences—children's experiences—actually affect the expression of their genes. There is some Lothian Birth Cohort Wave 2 DNA methylation data were used to generate an epigenetic score for smoking - known as EpiSmokEr 20 in the sample. Based on genome-wide DNAm data of 396 mother-newborn pairs (54.5% male) from the Boston Birth Cohort, we found significant differences in mother-newborn correlations for overall DNAm patterns by newborn sex, with mother-female pairs having stronger correlations. More than 7 million individuals have been conceived by Assisted Reproductive Technologies (ART) and there is clear evidence that ART is associated with a range of adverse early life outcomes, including rare imprinting disorders. Worldwide, more than 1 in 10 infants is born prior to 37 weeks gestation. 126 (3):364-373. We found that father's BMI was associated with infant birth weight and with DNA methylation at several genetic loci in the offspring. Authors Michele Zemplenyi (1) - Mark J. Meyer (2) - Andres Cardenas (3) - n Marie-France Hivert (4 - 9) - Sheryl L. Rifas-Shiman (4) - Heike Gibson (5) - n Itai Kloog (6) - Joel Schwartz (5 - 8) - Emily Oken (4) - Dawn L. DeMeo (7) - n Diane R. Gold (5 - 8) - Brent A. Coull ((1) Department of Biostatistics - n Harvard T.H. . 3. RESEARCH PAPER Regulation of birthweight by placenta-derived miRNAs: evidence from an arsenic-exposed birth cohort in Bangladesh Mohammad L. Rahman a, Liming Liang b, Linda Valeric,LiSu, Zhaozhong Zhu , Shangzhi Gaoa, Golam Mostofa d, Qazi Qamruzzaman , Russ Hauser a,e, Andrea Baccarellif, and David C. Christiani aDepartment of Environmental Health, Harvard T.H. 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